Ontology highlight
ABSTRACT:
SUBMITTER: Rolls A
PROVIDER: S-EPMC4621781 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Rolls Asya A Pang Wendy W WW Ibarra Ingrid I Colas Damien D Bonnavion Patricia P Korin Ben B Heller H Craig HC Weissman Irving L IL de Lecea Luis L
Nature communications 20151014
Many of the factors affecting the success of haematopoietic cell transplantation are still unknown. Here we show in mice that donor sleep deprivation reduces the ability of its haematopoietic stem cells (HSCs) to engraft and reconstitute the blood and bone marrow of an irradiated recipient by more than 50%. We demonstrate that sleep deprivation downregulates the expression of microRNA (miR)-19b, a negative regulator of the suppressor of cytokine signalling (SOCS) genes, which inhibit HSC migrati ...[more]