The human blood DNA methylome displays a highly distinctive profile compared with other somatic tissues.
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ABSTRACT:
SUBMITTER: Lowe R
PROVIDER: S-EPMC4622544 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
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The human blood DNA methylome displays a highly distinctive profile compared with other somatic tissues.
Lowe Robert R Slodkowicz Greg G Goldman Nick N Rakyan Vardhman K VK
Epigenetics 20150101 4
In mammals, DNA methylation profiles vary substantially between tissues. Recent genome-scale studies report that blood displays a highly distinctive methylomic profile from other somatic tissues. In this study, we sought to understand why blood DNA methylation state is so different to the one found in other tissues. We found that whole blood contains approximately twice as many tissue-specific differentially methylated positions (tDMPs) than any other somatic tissue examined. Furthermore, a larg ...[more]
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