Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC6792267 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Zhang Yiqun Y Yang Lixing L Kucherlapati Melanie M Hadjipanayis Angela A Pantazi Angeliki A Bristow Christopher A CA Lee Eunjung Alice EA Mahadeshwar Harshad S HS Tang Jiabin J Zhang Jianhua J Seth Sahil S Lee Semin S Ren Xiaojia X Song Xingzhi X Sun Huandong H Seidman Jonathan J Luquette Lovelace J LJ Xi Ruibin R Chin Lynda L Protopopov Alexei A Park Peter J PJ Kucherlapati Raju R Creighton Chad J CJ
Genome biology 20191015 1
<h4>Background</h4>Genomic rearrangements exert a heavy influence on the molecular landscape of cancer. New analytical approaches integrating somatic structural variants (SSVs) with altered gene features represent a framework by which we can assign global significance to a core set of genes, analogous to established methods that identify genes non-randomly targeted by somatic mutation or copy number alteration. While recent studies have defined broad patterns of association involving gene transc ...[more]