Ontology highlight
ABSTRACT:
SUBMITTER: Vicario A
PROVIDER: S-EPMC4624863 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Vicario Annalisa A Colliva Andrea A Ratti Antonia A Davidovic Laetitia L Baj Gabriele G Gricman Łukasz Ł Colombrita Claudia C Pallavicini Alberto A Jones Kevin R KR Bardoni Barbara B Tongiorgi Enrico E
Frontiers in molecular neuroscience 20151029
Sorting of mRNAs in neuronal dendrites relies upon inducible transport mechanisms whose molecular bases are poorly understood. We investigated here the mechanism of inducible dendritic targeting of rat brain-derived neurotrophic factor (BDNF) mRNAs as a paradigmatic example. BDNF encodes multiple mRNAs with either short or long 3' UTR, both hypothesized to harbor inducible dendritic targeting signals. However, the mechanisms of sorting of the two 3' UTR isoforms are controversial. We found that ...[more]