Epitope-Specific Anti-hCG Vaccines on a Virus Like Particle Platform.
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ABSTRACT:
SUBMITTER: Caldeira J
PROVIDER: S-EPMC4627648 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Epitope-Specific Anti-hCG Vaccines on a Virus Like Particle Platform.
Caldeira Jerri J Bustos Jeremiah J Peabody Julianne J Chackerian Bryce B Peabody David S DS
PloS one 20151030 10
The possibility of a contraceptive vaccine targeting human chorionic gonadotropin has long been recognized, but never fully realized. Here we describe an epitope-specific approach based on immunogenic display of hCG-derived peptides on virus-like particles of RNA bacteriophage. A number of recombinant VLPs were constructed, each displaying a different hCG-derived peptide. Some were taken from the disordered C-terminal tail of the hormone, another came from an internal loop, and yet another was a ...[more]
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