A Synthetic Aptamer-Drug Adduct for Targeted Liver Cancer Therapy.
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ABSTRACT:
SUBMITTER: Trinh TL
PROVIDER: S-EPMC4629891 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
A Synthetic Aptamer-Drug Adduct for Targeted Liver Cancer Therapy.
Trinh Thu Le TL Zhu Guizhi G Xiao Xilin X Puszyk William W Sefah Kwame K Wu Qunfeng Q Tan Weihong W Liu Chen C
PloS one 20151102 11
AS1411 (previously known as AGRO100) is a 26 nucleotide guanine-rich DNA aptamer which forms a guanine quadruplex structure. AS1411 has shown promising utility as a treatment for cancers in Phase I and Phase II clinical trials without causing major side-effects. AS1411 inhibits tumor cell growth by binding to nucleolin which is aberrantly expressed on the cell membrane of many tumors. In this study, we utilized a simple technique to conjugate a widely-used chemotherapeutic agent, doxorubicin (Do ...[more]
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