Ontology highlight
ABSTRACT:
SUBMITTER: Meng L
PROVIDER: S-EPMC3338807 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Meng Ling L Yang Liu L Zhao Xiangxuan X Zhang Lucy L Zhu Haizhen H Liu Chen C Tan Weihong W
PloS one 20120425 4
<h4>Background</h4>Using antibody/aptamer-drug conjugates can be a promising method for decreasing toxicity, while increasing the efficiency of chemotherapy.<h4>Methodology/principal findings</h4>In this study, the antitumor agent Doxorubicin (Dox) was incorporated into the modified DNA aptamer TLS11a-GC, which specifically targets LH86, a human hepatocellular carcinoma cell line. Cell viability tests demonstrated that the TLS11a-GC-Dox conjugates exhibited both potency and target specificity. I ...[more]