Melanoma: oncogenic drivers and the immune system.
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ABSTRACT:
SUBMITTER: Karachaliou N
PROVIDER: S-EPMC4630557 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Publications
Melanoma: oncogenic drivers and the immune system.
Karachaliou Niki N Pilotto Sara S Teixidó Cristina C Viteri Santiago S González-Cao María M Riso Aldo A Morales-Espinosa Daniela D Molina Miguel Angel MA Chaib Imane I Santarpia Mariacarmela M Richardet Eduardo E Bria Emilio E Rosell Rafael R
Annals of translational medicine 20151001 18
Advances and in-depth understanding of the biology of melanoma over the past 30 years have contributed to a change in the consideration of melanoma as one of the most therapy-resistant malignancies. The finding that oncogenic BRAF mutations drive tumor growth in up to 50% of melanomas led to a molecular therapy revolution for unresectable and metastatic disease. Moving beyond BRAF, inactivation of immune regulatory checkpoints that limit T cell responses to melanoma has provided targets for canc ...[more]
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