Ontology highlight
ABSTRACT:
SUBMITTER: Cho HS
PROVIDER: S-EPMC4635571 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Cho Hyoung-Soo HS Shin Hyun Mu HM Haberstock-Debic Helena H Xing Yan Y Owens Timothy D TD Funk Jens Oliver JO Hill Ronald J RJ Bradshaw J Michael JM Berg Leslie J LJ
Journal of immunology (Baltimore, Md. : 1950) 20151014 10
In T cells, the Tec kinases IL-2-inducible T cell kinase (ITK) and resting lymphocyte kinase (RLK) are activated by TCR stimulation and are required for optimal downstream signaling. Studies of CD4(+) T cells from Itk(-/-) and Itk(-/-)Rlk(-/-) mice have indicated differential roles of ITK and RLK in Th1, Th2, and Th17 differentiation and cytokine production. However, these findings are confounded by the complex T cell developmental defects in these mice. In this study, we examine the consequence ...[more]