Ontology highlight
ABSTRACT:
SUBMITTER: Venuto RC
PROVIDER: S-EPMC4635790 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Venuto Rocco C RC Meaney Calvin J CJ Chang Shirley S Leca Nicolae N Consiglio Joseph D JD Wilding Gregory E GE Brazeau Daniel D Gundroo Aijaz A Nainani Neha N Morse Sarah E SE Cooper Louise M LM Tornatore Kathleen M KM
Medicine 20150901 37
Extrarenal adverse effects (AEs) associated with calcineurin inhibitor (CNI) and mycophenolic acid (MPA) occur frequently but are unpredictable posttransplant complications. AEs may result from intracellular CNI accumulation and low activity of P-glycoprotein, encoded by the ABCB1 gene. Since ABCB1 single nucleotide polymorphisms (SNPs) and sex influence P-glycoprotein, we investigated haplotypes and extrarenal AEs. A prospective, cross-sectional study evaluated 149 patients receiving tacrolimus ...[more]