Ontology highlight
ABSTRACT:
SUBMITTER: Gaykalova DA
PROVIDER: S-EPMC4636259 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Gaykalova Daria A DA Vatapalli Rajita R Wei Yingying Y Tsai Hua-Ling HL Wang Hao H Zhang Chi C Hennessey Patrick T PT Guo Theresa T Tan Marietta M Li Ryan R Ahn Julie J Khan Zubair Z Westra William H WH Bishop Justin A JA Zaboli David D Koch Wayne M WM Khan Tanbir T Ochs Michael F MF Califano Joseph A JA
PloS one 20151106 11
Head and Neck Squamous Cell Carcinoma (HNSCC) is the fifth most common cancer, annually affecting over half a million people worldwide. Presently, there are no accepted biomarkers for clinical detection and surveillance of HNSCC. In this work, a comprehensive genome-wide analysis of epigenetic alterations in primary HNSCC tumors was employed in conjunction with cancer-specific outlier statistics to define novel biomarker genes which are differentially methylated in HNSCC. The 37 identified bioma ...[more]