Ontology highlight
ABSTRACT:
SUBMITTER: Kishibe M
PROVIDER: S-EPMC4637223 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Kishibe Mari M Griffin Tina M TM Radek Katherine A KA
International immunopharmacology 20150610 1
The cholinergic anti-inflammatory pathway spans several macro- and micro-environments to control inflammation via α7 nicotinic acetylcholine receptors (nAChRs). Physiologic inflammation is necessary for normal wound repair and is triggered, in part, via Toll-like receptors (TLRs). Here, we demonstrate that keratinocyte nAChR activation dampens TLR2-mediated migration and pro-inflammatory cytokine and antimicrobial peptide (AMP) production, which is restored by a α7-selective nAChR antagonist. Th ...[more]