Ontology highlight
ABSTRACT:
SUBMITTER: Byrne LM
PROVIDER: S-EPMC5844906 | biostudies-other | 2018 Mar
REPOSITORIES: biostudies-other
Byrne Lauren M LM Rodrigues Filipe B FB Johnson Eileanoir B EB De Vita Enrico E Blennow Kaj K Scahill Rachael R Zetterberg Henrik H Heslegrave Amanda A Wild Edward J EJ
Scientific reports 20180309 1
Biomarkers of Huntington's disease (HD) in cerebrospinal fluid (CSF) could be of value in elucidating the biology of this genetic neurodegenerative disease, as well as in the development of novel therapeutics. Deranged synaptic and immune function have been reported in HD, and concentrations of the synaptic protein neurogranin and the microglial protein TREM2 are increased in other neurodegenerative diseases. We therefore used ELISAs to quantify neurogranin and TREM2 in CSF samples from HD mutat ...[more]