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Synthesis of the benzo-fused indolizidine alkaloid mimics.

ABSTRACT: A general synthesis of various benzo-fused indolizidine alkaloid mimics has been developed. The indolizidine derivatives 8 were prepared via heteroaryl Grignard addition to N-acylpyridinium salts followed by an intramolecular Heck cyclization. Further substitution reactions were developed to demonstrate that heterocycles 8 are good scaffolds for chemical library preparation.

SUBMITTER: Comins DL

PROVIDER: S-EPMC2200666 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature

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Synthesis of the benzo-fused indolizidine alkaloid mimics.

Comins Daniel L DL Higuchi Kazuhiro K

Beilstein journal of organic chemistry 20071130

A general synthesis of various benzo-fused indolizidine alkaloid mimics has been developed. The indolizidine derivatives 8 were prepared via heteroaryl Grignard addition to N-acylpyridinium salts followed by an intramolecular Heck cyclization. Further substitution reactions were developed to demonstrate that heterocycles 8 are good scaffolds for chemical library preparation. ...[more]

PMID: 18047680

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