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Variant of PAI-2 gene is associated with coronary artery disease and recurrent coronary event risk in Chinese Han population.

ABSTRACT: Plasminogen activator inhibitor -2 (PAI-2) is an important molecular that plays a crucial role in vascular homeostasis and constitutes a critical response mechanism to cardiovascular injury, such as atherosclerosis, coronary artery disease (CAD).The aim of the current study was to explore the association between the variants in PAI-2 gene and CAD and its prognoses. The three variants (rs8093048, rs9946657, rs9320032) of the PAI-2 gene were detected in 407 patients with CAD and 518 control subjects. All patients with CAD underwent one-year follow-up for major adverse cardiac events (MACE).The frequencies of the TT genotype and T allele of rs8093048 was significantly higher in CAD patients than that in control subjects (7.6% vs.3.5%, P?=?0.003, 28.1 % vs.21.7%, P?

SUBMITTER: Li X

PROVIDER: S-EPMC4647573 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Variant of PAI-2 gene is associated with coronary artery disease and recurrent coronary event risk in Chinese Han population.

Li Xia X Luo Jun-Yi JY Zhang Lei L Yang Yi-Ning YN Xie Xiang X Liu Fen F Chen Bang-Dang BD Ma Yi-Tong YT

Lipids in health and disease 20151116

<h4>Background</h4>Plasminogen activator inhibitor -2 (PAI-2) is an important molecular that plays a crucial role in vascular homeostasis and constitutes a critical response mechanism to cardiovascular injury, such as atherosclerosis, coronary artery disease (CAD).<h4>Methods</h4>The aim of the current study was to explore the association between the variants in PAI-2 gene and CAD and its prognoses. The three variants (rs8093048, rs9946657, rs9320032) of the PAI-2 gene were detected in 407 patie ...[more]

PMID: 26573152

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