Zinc binding to human lactogenic hormones and the human prolactin receptor.
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ABSTRACT:
SUBMITTER: Voorhees JL
PROVIDER: S-EPMC4648361 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Publications
Zinc binding to human lactogenic hormones and the human prolactin receptor.
Voorhees Jeffrey L JL Rao Geeta Vittal GV Gordon Timothy J TJ Brooks Charles L CL
FEBS letters 20110415 12
Zinc half sites are present in all human lactogenic hormones: human prolactin (hPRL), growth hormone (hGH), placental lactogens (hPL) and the hPRL receptor (hPRLr). The influence of divalent zinc (Zn(2+)) as measured by intrinsic fluorescence or FRET in each of these hormones is unique and is affected by the presence of varying stoichiometries of hPRLr. These data show that both Zn(2+) and hPRLr binding influence hPRL conformers in an interdependent fashion. Although each of these three lactogen ...[more]
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