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Seed migration after transperineal interstitial prostate brachytherapy by using loose seeds: Japanese prostate cancer outcome study of permanent iodine-125 seed implantation (J-POPS) multi-institutional cohort study.


ABSTRACT: The incidence and associated factors of loose seed migration were investigated in cohort 1 of the Japanese Prostate Cancer Outcome Study of Permanent Iodine-125 Seed Implantation (J-POPS).The study subjects were 2160 patients, consisting of 1641 patients who underwent permanent iodine-125 seed implantation (PI) and 519 patients who underwent PI combined with external beam radiation therapy (PI?+?EBRT). The presence or absence of seed migration to the chest and abdominal/pelvic region was determined.Seed migration was observed in 22.7 % of PI group patients and 18.1 % of PI?+?EBRT group patients (p?=?0.0276). Migration to the lungs and abdominal/pelvic region was observed in 14.6 % and 11.1 % of the patients in the PI group, and 11.2 % and 8.5 % of the patients in the PI?+?EBRT group, respectively. In the PI group, the number of implanted seeds was associated with the seed migration incidence. Neither the PI nor the PI?+?EBRT group showed any difference in the volume of the prostate receiving 100 % of the prescribed dose (V100 [%]) or the minimal dose received by 90 % of the prostate volume (D90 [Gy]) between the patients with and without seed migration.This prospective cohort study investigating the largest number of past cases showed no difference in D90 (Gy) or V100 (%) between seed migration or the absence thereof in both the PI group and PI?+?EBRT group.ClinicalTrials.gov: NCT00534196.

SUBMITTER: Nakano M 

PROVIDER: S-EPMC4650265 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature

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Seed migration after transperineal interstitial prostate brachytherapy by using loose seeds: Japanese prostate cancer outcome study of permanent iodine-125 seed implantation (J-POPS) multi-institutional cohort study.

Nakano Masahiro M   Yorozu Atsunori A   Saito Shiro S   Sugawara Akitomo A   Maruo Shinichiroh S   Kojima Shinsuke S   Kikuchi Takashi T   Fukushima Masanori M   Dokiya Takushi T   Yamanaka Hidetoshi H  

Radiation oncology (London, England) 20151114


<h4>Background</h4>The incidence and associated factors of loose seed migration were investigated in cohort 1 of the Japanese Prostate Cancer Outcome Study of Permanent Iodine-125 Seed Implantation (J-POPS).<h4>Methods</h4>The study subjects were 2160 patients, consisting of 1641 patients who underwent permanent iodine-125 seed implantation (PI) and 519 patients who underwent PI combined with external beam radiation therapy (PI + EBRT). The presence or absence of seed migration to the chest and  ...[more]

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