Ontology highlight
ABSTRACT:
SUBMITTER: Kusano S
PROVIDER: S-EPMC4652779 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Nucleic acids research 20150805 16
DNA interstrand crosslinks (ICLs) are the primary mechanism for the cytotoxic activity of many clinical anticancer drugs, and numerous strategies for forming ICLs have been developed. One such method is using crosslink-forming oligonucleotides (CFOs). In this study, we designed a 4-amino-6-oxo-2-vinylpyrimidine (AOVP) derivative with an acyclic spacer to react selectively with guanine. The AOVP CFO exhibited selective crosslinking reactivity with guanine and thymine in DNA, and with guanine in R ...[more]