Ontology highlight
ABSTRACT:
SUBMITTER: Warren EA
PROVIDER: S-EPMC4653655 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Warren Emilie A K EA Netterfield Tatiana S TS Sarkar Saheli S Kemp Melissa L ML Payne Christine K CK
Scientific reports 20151120
Understanding intracellular redox chemistry requires new tools for the site-specific visualization of intracellular oxidation. We have developed a spatially-resolved intracellular sensor of hydrogen peroxide, HyPer-Tau, for time-resolved imaging in live cells. This sensor consists of a hydrogen peroxide-sensing protein tethered to microtubules. We demonstrate the use of the HyPer-Tau sensor for three applications; dose-dependent response of human cells to exogenous hydrogen peroxide, a model imm ...[more]