Ontology highlight
ABSTRACT:
SUBMITTER: Brodeur TY
PROVIDER: S-EPMC4655158 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Brodeur Tia Y TY Robidoux Tara E TE Weinstein Jason S JS Craft Joseph J Swain Susan L SL Marshak-Rothstein Ann A
Journal of immunology (Baltimore, Md. : 1950) 20151030 11
Type 2 effector production of IL-13, a demonstrated requirement in models of fibrosis, is routinely ascribed to CD4(+) Th2 cells. We now demonstrate a major role for CD8(+) T cells in a murine model of sterile lung injury. These pulmonary CD8(+) T cells differentiate into IL-13-producing Tc2 cells and play a major role in a bleomycin-induced model of fibrosis. Differentiation of these Tc2 cells in the lung requires IL-21, and bleomycin treated IL-21- and IL-21R-deficient mice develop inflammatio ...[more]