Ontology highlight
ABSTRACT:
SUBMITTER: Mittal A
PROVIDER: S-EPMC7293547 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Mittal Akanksha A Murugaiyan Gopal G Beynon Vanessa V Hu Dan D Weiner Howard L HL
Immunology and cell biology 20120320 8
Interleukin (IL)-27 exerts an anti-inflammatory effect on human and mice CD4(+) T cells by inducing IL-10-producing T regulatory 1 cells through induction of IL-21. However, the role of IL-27 and how it regulates IL-21 from human CD8(+) T cells is unclear. Here, we show that the IL-27 receptor is expressed on human CD8(+) T cells and stimulation of human naïve CD8(+) T cells in the presence of IL-27 leads to an increase in IL-21 and interferon (IFN)-γ production. IL-21 induction in IL-27-stimula ...[more]