Ontology highlight
ABSTRACT:
SUBMITTER: Paik PK
PROVIDER: S-EPMC4658654 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Paik Paul K PK Drilon Alexander A Fan Pang-Dian PD Yu Helena H Rekhtman Natasha N Ginsberg Michelle S MS Borsu Laetitia L Schultz Nikolaus N Berger Michael F MF Rudin Charles M CM Ladanyi Marc M
Cancer discovery 20150513 8
<h4>Unlabelled</h4>Mutations in the MET exon 14 RNA splice acceptor and donor sites, which lead to exon skipping, deletion of the juxtamembrane domain containing the CBL E3-ubiquitin ligase-binding site, and decreased turnover of the resultant aberrant MET protein, were previously reported to be oncogenic in preclinical models. We now report responses to the MET inhibitors crizotinib and cabozantinib in four patients with stage IV lung adenocarcinomas harboring mutations leading to MET exon 14 s ...[more]