Ontology highlight
ABSTRACT:
SUBMITTER: Lung J
PROVIDER: S-EPMC6675391 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Lung Jrhau J Hung Ming-Szu MS Lin Yu-Ching YC Lee Kam-Fai KF Jiang Yuan Yuan YY Huang Shao-Lan SL Fang Yu-Hung YH Lu Ming-Shian MS Lin Chin-Kuo CK Yang Tsung-Ming TM Lin Paul Yann PY Hsieh Meng-Jer MJ Tsai Ying Huang YH
PloS one 20190801 8
Somatic mutations of MET gene are emerging as important driver mutations for lung cancers. To identify the common clinicopathological features of MET exon 14 skipping mutations and amplification and clarify whether the two MET gene alterations cause protein overexpression were investigated using 196 lung cancer samples of Taiwan through real time-qPCR/sequencing, fluorescence in situ hybridization, and immunohistochemistry. The two MET gene alterations are both present in low frequency, ~1%, in ...[more]