Ontology highlight
ABSTRACT:
SUBMITTER: Cantini L
PROVIDER: S-EPMC4660217 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Cantini Laura L Isella Claudio C Petti Consalvo C Picco Gabriele G Chiola Simone S Ficarra Elisa E Caselle Michele M Medico Enzo E
Nature communications 20151117
Colorectal cancer (CRC) transcriptional subtypes have been recently identified by gene expression profiling. Here we describe an analytical pipeline, microRNA master regulator analysis (MMRA), developed to search for microRNAs potentially driving CRC subtypes. Starting from a microRNA-mRNA tumour expression data set, MMRA identifies candidate regulator microRNAs by assessing their subtype-specific expression, target enrichment in subtype mRNA signatures and network analysis-based contribution to ...[more]