Ontology highlight
ABSTRACT:
SUBMITTER: Allende-Vega N
PROVIDER: S-EPMC4662487 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Oncotarget 20150801 22
Manipulation of metabolic pathways in hematological cancers has therapeutic potential. Here, we determined the molecular mechanism of action of the metabolic modulator dichloroacetate (DCA) in leukemic cells. We found that DCA induces the AMP-activated protein kinase (AMPK)/p53 pathway with increased efficacy in tumors expressing wild type (wt p53). Clinically relevant, low concentrations of doxorubicin synergize in vitro and in vivo with DCA to further enhance p53 activation and to block tumor ...[more]