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Cross-sectional study of factors influencing sex hormone-binding globulin concentrations in normally cycling premenopausal women.

ABSTRACT: To assess the relationship between SHBG and 18 other hormonal and metabolic parameters in well characterized, normally cycling premenopausal women.Cross-sectional study.University general clinical research center.A total of 319 young healthy women with ovulatory menstrual cycles.None.Midfollicular serum SHBG concentrations.In our final linear regression model, SHBG was negatively associated with bioavailable T and positively associated with adiponectin, associations that were independent from other parameters. SHBG was also positively associated with estrone sulfate, but only when taking into account confounding variables. Unexpectedly, there was no straightforward relationship between SHBG and insulin resistance according to homeostasis-model assessment.Our results highlight the link between androgen action, as reflected by bioavailable T, and circulating SHBG concentrations in all premenopausal women and speak to the importance of the relationship between SHBG and adiponectin, which is at least in part independent from androgen action.NCT00393172.

SUBMITTER: Crawford TN

PROVIDER: S-EPMC4663171 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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Cross-sectional study of factors influencing sex hormone-binding globulin concentrations in normally cycling premenopausal women.

Crawford Talia N TN Arikawa Andrea Y AY Kurzer Mindy S MS Schmitz Kathryn H KH Phipps William R WR

Fertility and sterility 20150916 6

<h4>Objective</h4>To assess the relationship between SHBG and 18 other hormonal and metabolic parameters in well characterized, normally cycling premenopausal women.<h4>Design</h4>Cross-sectional study.<h4>Setting</h4>University general clinical research center.<h4>Subject(s)</h4>A total of 319 young healthy women with ovulatory menstrual cycles.<h4>Intervention(s)</h4>None.<h4>Main outcome measure(s)</h4>Midfollicular serum SHBG concentrations.<h4>Result(s)</h4>In our final linear regression mo ...[more]

PMID: 26385402

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Project description:Essentials Endogenous hormone levels' influence on hemostatic factor levels is not fully characterized. We tested for associations of endogenous hormone with hemostatic factor levels in postmenopause. Estrone levels were inversely associated with the natural anticoagulant, protein S antigen. Dehydroepiandrosterone sulfate levels were inversely associated with thrombin generation.SummaryBackground Oral use of exogenous estrogen/progestin alters hemostatic factor levels. The influence of endogenous hormones on these levels is incompletely characterized. Objectives Our study aimed to test whether, among postmenopausal women, high levels of estradiol (E2), estrone (E1), testosterone (T), dehydroepiandrosterone sulfate (DHEAS), dehydroepiandrosterone (DHEA), and androstenedione, and low levels of sex hormone-binding globulin (SHBG), are positively associated with measures of thrombin generation (TG), a normalized activated protein C sensitivity ratio (nAPCsr), and factor VII activity (FVIIc), and negatively associated with antithrombin activity (ATc) and total protein S antigen (PSAg). Methods This Heart and Vascular Health study cross-sectional analysis included 131 postmenopausal women without a prior venous thrombosis who were not currently using hormone therapy. Adjusted mean differences in TG, nAPCsr, FVIIc, ATc and PSAg levels associated with differences in hormone levels were estimated using multiple linear regression. We measured E2, E1, total T, DHEAS, DHEA and androstenedione levels by mass spectrometry, SHBG levels by immunoassay, and calculated the level of free T. Results One picogram per milliliter higher E1 levels were associated with 0.24% lower PSAg levels (95% Confidence Interval [CI]: -0.35, -0.12) and 1 μg mL-1 higher DHEAS levels were associated with 40.8 nm lower TG peak values (95% CI: -59.5, -22.2) and 140.7 nm×min lower TG endogenous thrombin potential (ETP) (95% CI: -212.1, -69.4). After multiple comparisons correction, there was no evidence for other associations. Conclusions As hypothesized, higher E1 levels were associated with lower levels of the natural anticoagulant PSAg. Contrary to hypotheses, higher DHEAS levels were associated with differences in TG peak and ETP that suggest less generation of thrombin.

Dataset Information

Cross-sectional study of factors influencing sex hormone-binding globulin concentrations in normally cycling premenopausal women.

Publications

Cross-sectional study of factors influencing sex hormone-binding globulin concentrations in normally cycling premenopausal women.

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