Dataset Information

High resolution pituitary gland MRI at 7.0 tesla: a clinical evaluation in Cushing's disease.

ABSTRACT:

Objective

To evaluate the detection of pituitary lesions at 7.0 T compared to 1.5 T MRI in 16 patients with clinically and biochemically proven Cushing's disease.

Methods

In seven patients, no lesion was detected on the initial 1.5 T MRI, and in nine patients it was uncertain whether there was a lesion. Firstly, two readers assessed both 1.5 T and 7.0 T MRI examinations unpaired in a random order for the presence of lesions. Consensus reading with a third neuroradiologist was used to define final lesions in all MRIs. Secondly, surgical outcome was evaluated. A comparison was made between the lesions visualized with MRI and the lesions found during surgery in 9/16 patients.

Results

The interobserver agreement for lesion detection was good at 1.5 T MRI (? = 0.69) and 7.0 T MRI (? = 0.62). In five patients, both the 1.5 T and 7.0 T MRI enabled visualization of a lesion on the correct side of the pituitary gland. In three patients, 7.0 T MRI detected a lesion on the correct side of the pituitary gland, while no lesion was visible at 1.5 T MRI.

Conclusion

The interobserver agreement of image assessment for 7.0 T MRI in patients with Cushing's disease was good, and lesions were detected more accurately with 7.0 T MRI.

Key points

Interobserver agreement for lesion detection on 1.5 T MRI was good; Interobserver agreement for lesion detection on 7.0 T MRI was good; 7.0 T enabled confirmation of unclear lesions at 1.5 T; 7.0 T enabled visualization of lesions not visible at 1.5 T.

SUBMITTER: de Rotte AA

PROVIDER: S-EPMC4666272 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature

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Publications

High resolution pituitary gland MRI at 7.0 tesla: a clinical evaluation in Cushing's disease.

de Rotte Alexandra A J AA Groenewegen Amy A Rutgers Dik R DR Witkamp Theo T Zelissen Pierre M J PM Meijer F J Anton FJ van Lindert Erik J EJ Hermus Ad A Luijten Peter R PR Hendrikse Jeroen J

European radiology 20150520 1

<h4>Objective</h4>To evaluate the detection of pituitary lesions at 7.0 T compared to 1.5 T MRI in 16 patients with clinically and biochemically proven Cushing's disease.<h4>Methods</h4>In seven patients, no lesion was detected on the initial 1.5 T MRI, and in nine patients it was uncertain whether there was a lesion. Firstly, two readers assessed both 1.5 T and 7.0 T MRI examinations unpaired in a random order for the presence of lesions. Consensus reading with a third neuroradiologist was used ...[more]

PMID: 25991481

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Dataset Information

High resolution pituitary gland MRI at 7.0 tesla: a clinical evaluation in Cushing's disease.

Objective

Methods

Results

Conclusion

Key points

Publications

High resolution pituitary gland MRI at 7.0 tesla: a clinical evaluation in Cushing's disease.

Similar Datasets

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