Ontology highlight
ABSTRACT:
SUBMITTER: Yelagandula R
PROVIDER: S-EPMC4671829 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Yelagandula Ramesh R Stroud Hume H Holec Sarah S Zhou Keda K Feng Suhua S Zhong Xuehua X Muthurajan Uma M UM Nie Xin X Kawashima Tomokazu T Groth Martin M Luger Karolin K Jacobsen Steven E SE Berger Frédéric F
Cell 20140701 1
Histone variants play crucial roles in gene expression, genome integrity, and chromosome segregation. We report that the four H2A variants in Arabidopsis define different genomic features, contributing to overall genomic organization. The histone variant H2A.W marks heterochromatin specifically and acts in synergy with heterochromatic marks H3K9me2 and DNA methylation to maintain transposon silencing. In vitro, H2A.W enhances chromatin condensation by promoting fiber-to-fiber interactions via it ...[more]