Ontology highlight
ABSTRACT:
SUBMITTER: Gouge J
PROVIDER: S-EPMC4671959 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Gouge Jerome J Satia Karishma K Guthertz Nicolas N Widya Marcella M Thompson Andrew James AJ Cousin Pascal P Dergai Oleksandr O Hernandez Nouria N Vannini Alessandro A
Cell 20151201 6
TFIIB-related factor 2 (Brf2) is a member of the family of TFIIB-like core transcription factors. Brf2 recruits RNA polymerase (Pol) III to type III gene-external promoters, including the U6 spliceosomal RNA and selenocysteine tRNA genes. Found only in vertebrates, Brf2 has been linked to tumorigenesis but the underlying mechanisms remain elusive. We have solved crystal structures of a human Brf2-TBP complex bound to natural promoters, obtaining a detailed view of the molecular interactions occu ...[more]