Ontology highlight
ABSTRACT:
SUBMITTER: Knutson BA
PROVIDER: S-EPMC3319074 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20110901 6049
Eukaryotic and archaeal multisubunit RNA polymerases (Pols) are structurally related and require several similar components for transcription initiation. However, none of the Pol I factors were known to share homology with transcription factor IIB (TFIIB) or TFIIB-related proteins, key factors in the initiation mechanisms of the other Pols. Here we show that Rrn7, a subunit of the yeast Pol I core factor, and its human ortholog TAF1B are TFIIB-like factors. Although distantly related, Rrn7 share ...[more]