Ontology highlight
ABSTRACT:
SUBMITTER: Ferri ML
PROVIDER: S-EPMC85110 | biostudies-literature | 2000 Jan
REPOSITORIES: biostudies-literature
Ferri M L ML Peyroche G G Siaut M M Lefebvre O O Carles C C Conesa C C Sentenac A A
Molecular and cellular biology 20000101 2
There is limited information on how eukaryotic RNA polymerases (Pol) recognize their cognate preinitiation complex. We have characterized a polypeptide copurifying with yeast Pol III. This protein, C17, was found to be homologous to a mammalian protein described as a hormone receptor. Deletion of the corresponding gene, RPC17, was lethal and its regulated extinction caused a selective defect in transcription of class III genes in vivo. Two-hybrid and coimmunoprecipitation experiments indicated t ...[more]