Ontology highlight
ABSTRACT:
SUBMITTER: Chitalia VC
PROVIDER: S-EPMC2830866 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Chitalia Vipul C VC Foy Rebecca L RL Bachschmid Markus M MM Zeng Liling L Panchenko Maria V MV Zhou Mina I MI Bharti Ajit A Seldin David C DC Lecker Stewart H SH Dominguez Isabel I Cohen Herbert T HT
Nature cell biology 20080921 10
The von Hippel-Lindau protein pVHL suppresses renal tumorigenesis in part by promoting the degradation of hypoxia-inducible HIF-alpha transcription factors; additional mechanisms have been proposed. pVHL also stabilizes the plant homeodomain protein Jade-1, which is a candidate renal tumour suppressor that may correlate with renal cancer risk. Here we show that Jade-1 binds the oncoprotein beta-catenin in Wnt-responsive fashion. Moreover, Jade-1 destabilizes wild-type beta-catenin but not a canc ...[more]