Ontology highlight
ABSTRACT:
SUBMITTER: Romero P
PROVIDER: S-EPMC4676826 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Romero Philipp P Schmitteckert Stefanie S Wouters Mira M MM Houghton Lesley A LA Czogalla Bastian B Sayuk Gregory S GS Boeckxstaens Guy E GE Guenther Patrick P Holland-Cunz Stefan S Niesler Beate B
BMC medical genetics 20151211
<h4>Background</h4>The calcium-sensing receptor (CaSR) is a calcium (Ca(2+)) sensitive G protein-coupled receptor implicated in various biological processes. In particular, it regulates Ca(2+)/Mg(2+)- homeostasis and senses interstitial Ca(2+) levels and thereby controls downstream signalling cascades. Due to its expression in the gut epithelium, the enteric nervous system and smooth muscles and its key function in regulation and coordination of muscular contraction and secretion, it represents ...[more]