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ABSTRACT:
SUBMITTER: Bokor E
PROVIDER: S-EPMC4677374 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Bokor Éva É Kun Sándor S Docsa Tibor T Gergely Pál P Somsák László L
ACS medicinal chemistry letters 20151019 12
Inhibition of glycogen phosphorylases may lead to pharmacological treatments of diseases in which glycogen metabolism plays an important role: first of all in diabetes, but also in cardiovascular and tumorous disorders. C-(β-d-Glucopyranosyl) isoxazole, pyrazole, thiazole, and imidazole type compounds were synthesized, and the latter showed the strongest inhibition against rabbit muscle glycogen phosphorylase b. Most efficient was 2-(β-d-glucopyranosyl)-4(5)-(2-naphthyl)-imidazole (11b, K i = 31 ...[more]