Ontology highlight
ABSTRACT:
SUBMITTER: Mavreas KF
PROVIDER: S-EPMC7700572 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Mavreas Konstantinos F KF Neofytos Dionysios D DD Chrysina Evangelia D ED Venturini Alessandro A Gimisis Thanasis T
Molecules (Basel, Switzerland) 20201122 22
Dysregulation of glycogen phosphorylase, an enzyme involved in glucose homeostasis, may lead to a number of pathological states such as type 2 diabetes and cancer, making it an important molecular target for the development of new forms of pharmaceutical intervention. Based on our previous work on the design and synthesis of 4-arylamino-1-(β-d-glucopyranosyl)pyrimidin-2-ones, which inhibit the activity of glycogen phosphorylase by binding at its catalytic site, we report herein a general synthes ...[more]