Ontology highlight
ABSTRACT:
SUBMITTER: Stathi A
PROVIDER: S-EPMC6630470 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Stathi Aggeliki A Mamais Michael M Chrysina Evangelia D ED Gimisis Thanasis T
Molecules (Basel, Switzerland) 20190625 12
In the case of type 2 diabetes, inhibitors of glycogen phosphorylase (GP) may prevent unwanted glycogenolysis under high glucose conditions and thus aim at the reduction of excessive glucose production by the liver. Anomeric spironucleosides, such as hydantocidin, present a rich synthetic chemistry and important biological function (e.g., inhibition of GP). For this study, the Suárez radical methodology was successfully applied to synthesize the first example of a 1,6-dioxa-4-azaspiro[4.5]decane ...[more]