Ontology highlight
ABSTRACT:
SUBMITTER: Lankenau MA
PROVIDER: S-EPMC4679059 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Lankenau Malori A MA Patel Ravi R Liyanarachchi Sandya S Maharry Sophia E SE Hoag Kevin W KW Duggan Megan M Walker Christopher J CJ Markowitz Joseph J Carson William E WE Eisfeld Ann-Kathrin AK de la Chapelle Albert A
Proceedings of the National Academy of Sciences of the United States of America 20151118 49
The B-Raf proto-oncogene serine/threonine kinase (BRAF) gene is the most frequently mutated gene in malignant melanoma (MM) and papillary thyroid cancer (PTC) and is causally involved in malignant cell transformation. Mutated BRAF is associated with an aggressive disease phenotype, thus making it a top candidate for targeted treatment strategies in MM and PTC. We show that BRAF mutations in both MM and PTC drive increased expression of oncomiR-3151, which is coactivated by the SP1/NF-κB complex. ...[more]