Development of Soft Tissue Sarcomas in Ribosomal Proteins L5 and S24 Heterozygous Mice.
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ABSTRACT:
SUBMITTER: Kazerounian S
PROVIDER: S-EPMC4679378 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Publications
Development of Soft Tissue Sarcomas in Ribosomal Proteins L5 and S24 Heterozygous Mice.
Kazerounian Shideh S Ciarlini Pedro D S C PD Yuan Daniel D Ghazvinian Roxanne R Alberich-Jorda Meritxell M Joshi Mugdha M Zhang Hong H Beggs Alan H AH Gazda Hanna T HT
Journal of Cancer 20160101 1
Diamond-Blackfan anemia (DBA) is an inherited bone marrow failure syndrome associated with ribosomal protein (RP) gene mutations. Recent studies have also demonstrated an increased risk of cancer predisposition among DBA patients. In this study, we report the formation of soft tissue sarcoma in the Rpl5 and Rps24 heterozygous mice. Our observation suggests that even though one wild-type allele of the Rpl5 or Rps24 gene prevents anemia in these mice, it still predisposes them to cancer developmen ...[more]
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