Acid-suppressive medications and risk of colorectal cancer: results from three large prospective cohort studies.

ABSTRACT:

Background

Despite several plausible biological mechanisms linking proton pump inhibitors (PPIs) and H2 receptor antagonists (H2RAs) with colorectal tumorigenesis, their association with risk of colorectal cancer (CRC) has not been adequately assessed in prospective epidemiological studies.

Methods

We evaluated the association of acid-suppressive medication use with CRC risk among 175,871 (PPI) and 208,831 (H2RA) participants from three large prospective cohort studies. Medication use was assessed at baseline and updated biennially. The association was evaluated using multivariate Cox proportional hazards regression models.

Results

There was no significant association between baseline PPI use (hazard ratio (HR) = 0.89, 95% confidence interval (CI), 0.71-1.12) or PPI u

SUBMITTER: Babic A 

PROVIDER: S-EPMC7462971 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature