Ontology highlight
ABSTRACT:
SUBMITTER: Kanellopoulou C
PROVIDER: S-EPMC4682067 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Kanellopoulou Chryssa C Gilpatrick Timothy T Kilaru Gokhul G Burr Patrick P Nguyen Cuong K CK Morawski Aaron A Lenardo Michael J MJ Muljo Stefan A SA
Stem cell reports 20151105 6
Members of the miR-290 family are the most abundantly expressed microRNAs (miRNAs) in mouse embryonic stem cells (ESCs). They regulate aspects of differentiation, pluripotency, and proliferation of ESCs, but the molecular program that they control has not been fully delineated. In the absence of Dicer, ESCs fail to express mature miR-290 miRNAs and have selective aberrant overexpression of Hoxa, Hoxb, Hoxc, and Hoxd genes essential for body plan patterning during embryogenesis, but they do not u ...[more]