BECLIN 1-VPS34 COMPLEX ARCHITECTURE: UNDERSTANDING THE NUTS AND BOLTS OF THERAPEUTIC TARGETS.
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ABSTRACT:
SUBMITTER: Morris DH
PROVIDER: S-EPMC4682202 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
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BECLIN 1-VPS34 COMPLEX ARCHITECTURE: UNDERSTANDING THE NUTS AND BOLTS OF THERAPEUTIC TARGETS.
Morris Deanna H DH Yip Calvin K CK Shi Yi Y Chait Brian T BT Wang Qing Jun QJ
Frontiers in biology 20151001 5
Autophagy is an important lysosomal degradation pathway that aids in the maintenance of cellular homeostasis by breaking down and recycling intracellular contents. Dysregulation of autophagy is linked to a growing number of human diseases. The Beclin 1-Vps34 protein-protein interaction network is critical for autophagy regulation and is therefore essential to cellular integrity. Manipulation of autophagy, in particular via modulation of the action of the Beclin 1-Vps34 complexes, is considered a ...[more]
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