Ontology highlight
ABSTRACT:
SUBMITTER: Chuang KH
PROVIDER: S-EPMC4682466 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Chuang Kuang-Hsiang KH Whitney-Miller Christa L CL Chu Chin-Yi CY Zhou Zhongren Z Dokus M Katherine MK Schmit Shannon S Barry Christopher T CT
Hepatology (Baltimore, Md.) 20150506 2
<h4>Unlabelled</h4>Vascular invasion provides a direct route for tumor metastasis. The degree to which microRNA (miRNA) expression plays a role in tumor vascular invasion is unclear. Here, we report that miR-494 is up-regulated in human hepatocellular carcinoma (HCC) tumors with vascular invasion and can promote HCC cell invasiveness by gene inactivation of multiple invasion-suppressor miRNAs. Our results show that ten eleven translocation (TET) methylcytosine dioxygenase, predominantly TET1 in ...[more]