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FDPS cooperates with PTEN loss to promote prostate cancer progression through modulation of small GTPases/AKT axis.

ABSTRACT: Farnesyl diphosphate synthase (FDPS), a mevalonate pathway enzyme, is highly expressed in several cancers, including prostate cancer (PCa). To date, the mechanistic, functional, and clinical significance of FDPS in cancer remains unexplored. We evaluated the FDPS expression and its cancer-associated phenotypes using in vitro and in vivo methods in PTEN-deficient and sufficient human and mouse PCa cells and tumors. Interestingly, FDPS overexpression synergizes with PTEN deficiency in PTEN conditionally knockout mice (P?

SUBMITTER: Seshacharyulu P

PROVIDER: S-EPMC6597298 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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FDPS cooperates with PTEN loss to promote prostate cancer progression through modulation of small GTPases/AKT axis.

Seshacharyulu Parthasarathy P Rachagani Satyanarayana S Muniyan Sakthivel S Siddiqui Jawed A JA Cruz Eric E Sharma Sunandini S Krishnan Ramakrishnan R Killips Brigham J BJ Sheinin Yuri Y Lele Subodh M SM Smith Lynette M LM Talmon Geoffrey A GA Ponnusamy Moorthy P MP Datta Kaustubh K Batra Surinder K SK

Oncogene 20190326 26

Farnesyl diphosphate synthase (FDPS), a mevalonate pathway enzyme, is highly expressed in several cancers, including prostate cancer (PCa). To date, the mechanistic, functional, and clinical significance of FDPS in cancer remains unexplored. We evaluated the FDPS expression and its cancer-associated phenotypes using in vitro and in vivo methods in PTEN-deficient and sufficient human and mouse PCa cells and tumors. Interestingly, FDPS overexpression synergizes with PTEN deficiency in PTEN conditi ...[more]

PMID: 30914801

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