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E Proteins and ID Proteins: Helix-Loop-Helix Partners in Development and Disease.

ABSTRACT: The basic Helix-Loop-Helix (bHLH) proteins represent a well-known class of transcriptional regulators. Many bHLH proteins act as heterodimers with members of a class of ubiquitous partners, the E proteins. A widely expressed class of inhibitory heterodimer partners-the Inhibitor of DNA-binding (ID) proteins-also exists. Genetic and molecular analyses in humans and in knockout mice implicate E proteins and ID proteins in a wide variety of diseases, belying the notion that they are non-specific partner proteins. Here, we explore relationships of E proteins and ID proteins to a variety of disease processes and highlight gaps in knowledge of disease mechanisms.

SUBMITTER: Wang LH

PROVIDER: S-EPMC4684411 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature

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E Proteins and ID Proteins: Helix-Loop-Helix Partners in Development and Disease.

Wang Lan-Hsin LH Baker Nicholas E NE

Developmental cell 20151101 3

The basic Helix-Loop-Helix (bHLH) proteins represent a well-known class of transcriptional regulators. Many bHLH proteins act as heterodimers with members of a class of ubiquitous partners, the E proteins. A widely expressed class of inhibitory heterodimer partners-the Inhibitor of DNA-binding (ID) proteins-also exists. Genetic and molecular analyses in humans and in knockout mice implicate E proteins and ID proteins in a wide variety of diseases, belying the notion that they are non-specific pa ...[more]

PMID: 26555048

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Project description:The basic helix-loop-helix proteins are dimeric transcription factors that are found in almost all eukaryotes. In animals, they are important regulators of embryonic development, particularly in neurogenesis, myogenesis, heart development and hematopoiesis.

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Sequence and function of basic helix-loop-helix proteins required for stomatal development in Arabidopsis are deeply conserved in land plants.

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| S-EPMC3139685 | biostudies-literature

Transcriptional regulation of the Sex-lethal gene by helix-loop-helix proteins.

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