Ontology highlight
ABSTRACT:
SUBMITTER: Wang LH
PROVIDER: S-EPMC4684411 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Wang Lan-Hsin LH Baker Nicholas E NE
Developmental cell 20151101 3
The basic Helix-Loop-Helix (bHLH) proteins represent a well-known class of transcriptional regulators. Many bHLH proteins act as heterodimers with members of a class of ubiquitous partners, the E proteins. A widely expressed class of inhibitory heterodimer partners-the Inhibitor of DNA-binding (ID) proteins-also exists. Genetic and molecular analyses in humans and in knockout mice implicate E proteins and ID proteins in a wide variety of diseases, belying the notion that they are non-specific pa ...[more]