Ontology highlight
ABSTRACT:
SUBMITTER: Shamseddine AA
PROVIDER: S-EPMC4684640 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Advances in biological regulation 20141027
Our understanding of the functions of ceramide signaling has advanced tremendously over the past decade. In this review, we focus on the roles and regulation of neutral sphingomyelinase 2 (nSMase2), an enzyme that generates the bioactive lipid ceramide through the hydrolysis of the membrane lipid sphingomyelin. A large body of work has now implicated nSMase2 in a diverse set of cellular functions, physiological processes, and disease pathologies. We discuss different aspects of this enzyme's reg ...[more]