Ontology highlight
ABSTRACT:
SUBMITTER: Kang S
PROVIDER: S-EPMC4684997 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Kang SunAh S Keener Amanda B AB Jones Shannon Z SZ Benschop Robert J RJ Caro-Maldonado Alfredo A Rathmell Jeffrey C JC Clarke Stephen H SH Matsushima Glenn K GK Whitmire Jason K JK Vilen Barbara J BJ
Journal of immunology (Baltimore, Md. : 1950) 20151130 1
Memory B cell responses are vital for protection against infections but must also be regulated to prevent autoimmunity. Cognate T cell help, somatic hypermutation, and affinity maturation within germinal centers (GCs) are required for high-affinity memory B cell formation; however, the signals that commit GC B cells to the memory pool remain unclear. In this study, we identify a role for IgG-immune complexes (ICs), FcγRs, and BAFF during the formation of memory B cells in mice. We found that ear ...[more]