Ontology highlight
ABSTRACT:
SUBMITTER: Muller-Winkler J
PROVIDER: S-EPMC7604764 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Müller-Winkler Jennifer J Mitter Richard R Rappe Julie C F JCF Vanes Lesley L Schweighoffer Edina E Mohammadi Hamid H Wack Andreas A Tybulewicz Victor L J VLJ
The Journal of experimental medicine 20210201 2
Memory B cells (MBCs) are long-lived cells that form a critical part of immunological memory, providing rapid antibody responses to recurring infections. However, very little is known about signals controlling MBC survival. Previous work has shown that antigen is not required for MBC survival, but a requirement for the B cell antigen receptor (BCR) has not been tested. Other studies have shown that, unlike naive B cells, MBCs do not express BAFFR and their survival is independent of BAFF, the li ...[more]