Unknown

Dataset Information

0

IgG Immune Complexes Inhibit Naive T Cell Proliferation and Suppress Effector Function in Cytotoxic T Cells.


ABSTRACT: Elevated levels of circulating immune complexes are associated with autoimmunity and with worse prognoses in cancer. Here, we examined the effects of well-defined, soluble immune complexes (ICs) on human peripheral T cells. We demonstrate that IgG-ICs inhibit the proliferation and differentiation of a subset of naïve T cells but stimulate the division of another naïve-like T cell subset. Phenotypic analysis by multi-parameter flow cytometry and RNA-Seq were used to characterize the inhibited and stimulated T cells revealing that the inhibited subset presented immature features resembling those of recent thymic emigrants and non-activated naïve T cells, whereas the stimulated subset exhibited transcriptional features indicative of a more differentiated, early memory progenitor with a naïve-like phenotype. Furthermore, we show that while IgG1-ICs do not profoundly inhibit the proliferation of memory T cells, IgG1-ICs suppress the production of granzyme-β and perforin in cytotoxic memory T cells. Our findings reveal how ICs can link humoral immunity and T cell function.

SUBMITTER: Charab W 

PROVIDER: S-EPMC8383740 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

2021-06-26 | GSE166445 | GEO
| S-EPMC4676693 | biostudies-literature
| S-EPMC5290958 | biostudies-literature
| S-EPMC5256993 | biostudies-literature
| S-EPMC5003914 | biostudies-literature
| S-EPMC4684997 | biostudies-literature
| S-EPMC4225162 | biostudies-literature
| S-EPMC5748859 | biostudies-literature
| S-EPMC7128890 | biostudies-literature
| S-EPMC3470926 | biostudies-literature