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GIMAP1 Is Essential for the Survival of Naive and Activated B Cells In Vivo.

ABSTRACT: An effective immune system depends upon regulation of lymphocyte function and homeostasis. In recent years, members of the GTPases of the immunity associated protein (GIMAP) family were proposed to regulate T cell homeostasis. In contrast, little is known about their function and mode of action in B cells. We used a combination of transgenic mice and in vivo and in vitro techniques to conditionally and electively ablate GIMAP1 in resting and activated peripheral B cells. Our data suggest that GIMAP1 is absolutely essential for the survival of peripheral B cells, irrespective of their activation state. Together with recent data showing increased expression of GIMAP1 in B cell lymphomas, our work points to the possible potential of GIMAP1 as a target for manipulation in a variety of B cell-mediated diseases.

SUBMITTER: Webb LM

PROVIDER: S-EPMC4685748 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature

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GIMAP1 Is Essential for the Survival of Naive and Activated B Cells In Vivo.

Webb Louise M C LM Datta Preeta P Bell Sarah E SE Kitamura Daisuke D Turner Martin M Butcher Geoffrey W GW

Journal of immunology (Baltimore, Md. : 1950) 20151130 1

An effective immune system depends upon regulation of lymphocyte function and homeostasis. In recent years, members of the GTPases of the immunity associated protein (GIMAP) family were proposed to regulate T cell homeostasis. In contrast, little is known about their function and mode of action in B cells. We used a combination of transgenic mice and in vivo and in vitro techniques to conditionally and electively ablate GIMAP1 in resting and activated peripheral B cells. Our data suggest that GI ...[more]

PMID: 26621859

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