Ontology highlight
ABSTRACT:
SUBMITTER: Caldara-Festin G
PROVIDER: S-EPMC4687605 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Caldara-Festin Grace G Jackson David R DR Barajas Jesus F JF Valentic Timothy R TR Patel Avinash B AB Aguilar Stephanie S Nguyen MyChi M Vo Michael M Khanna Avinash A Sasaki Eita E Liu Hung-Wen HW Tsai Shiou-Chuan SC
Proceedings of the National Academy of Sciences of the United States of America 20151202 50
Aromatic polyketides make up a large class of natural products with diverse bioactivity. During biosynthesis, linear poly-β-ketone intermediates are regiospecifically cyclized, yielding molecules with defined cyclization patterns that are crucial for polyketide bioactivity. The aromatase/cyclases (ARO/CYCs) are responsible for regiospecific cyclization of bacterial polyketides. The two most common cyclization patterns are C7-C12 and C9-C14 cyclizations. We have previously characterized three mon ...[more]